I am facing exact the same problem: Switching from 1Password to Enpass was smooth in the beginning (1 vault, 1100+ entries) applause for that!
But working with Enpass since then is a pain: Several seconds to wait after each searching. I am syncing over WebDAV via Synology in our LAN, it doesn't make any different if I sync via network cable, via WLAN or disable syncing at all. The new Enpass 6.8 doesn't speed things up for me. I fiddled the setting (number count, show icons etc -- but that made no different.
It's good to read that I am the only one with this problem -- but it's somehow weird that this problem exists for such a long time.
MacPro with latest Mojave, MacBook Pro with latest Monterey 12.3.1