Just wanted to get a hint on how everybody else is using Enpass and at the same time show my setup.
I use an USB-wristband for portability. I've got one layer of bitlocker using aes128 autounlock with tpm) and within that the walletx with its own aes256. Instead of the Enpass Portable I've got Enpass desktop installed on my three PCs pointing to an USB drive. That way I split up meta settings for Enpass in the registry and vault on a removable drive. Also when frequently synchronizing, the performance is better when executables that aren't secret reside on a local drive.
I use cloud sync, so local backup isn't necessary. I only mount the USB stick and vault when required, and never run Enpass in the background.
Critical secrets like Google or Microsoft are not stored in the vault, only their TOTP.