Yep, same here. All of a sudden, this happend. My colleagues, who use the same version on the same version of MacOS have no issues!
When I start enpass, I can select the search input field and enter data, but all other icons on that level (top bar area) are non-responsive.
Luckily, the command keys still work, so most of the time I can continue working with enpass. unfortunately, I have no idea as to why this happens.