Since installing the enpass 6 beta I have been running into cases where chrome locks up on launch for over 60 seconds.
I have since discovered this is a cumulative effect of 3 settings:
OneDrive Being allowed to sync all of Documents:
Enpass 6 storing its tmp directory in documents: C:\Users\<user>\OneDrive\Documents\Enpass6-Beta\.sync
The Enpass Password Manager extension for Chrome using the .sync directory on launch.
The fix is pretty simple in Microsoft OneDrive Settings -> Account -> Choose Folders unselect the enpass directory
Since most of my settings were default, I expect others are having the same issue and are not sure how to fix it, hopefully this helps.