I am experiencing the same issue described in this older post. What happens is:
Enpass goes idle.
I unlock it in the Chrome browser extension.
It waits for a little while, and tells me that Enpass is empty.
If I check the Enpass desktop app for MacOS, it also says it's empty.
I can fix this temporarily but closing Enpass, and reopening it. However, this is annoying. I've had to do this twice this morning already, and many times over the past week.
I'm running Enpass 6.6.0 (772), on an M1 MacBook Air, running MacOS 11.2.1 (20D74).