I'm not certain, but I suspect the trouble I encountered may be related to the trouble reported by @wmc in topic 28288, Enpass 6.7.4 (933) loses connection to databas.
TLDR
Before you make any changes to your Enpass setup, make certain you have a recent backup of your Enpass vault.
If you use Enpass Windows API (Win32) edition--you download the installer from the Enpass website--remove/uninstall Enpass Microsoft Store edition if it is installed. If Enpass Microsoft Store edition is installed, it will appear as Enpass Password Manager in the Windows Settings (Apps > Apps & features) app. If installed, Enpass Windows API edition will also appear in this list and will appear simply as Enpass. Do not uninstall this edition.
Repair Enpass Windows API edition. In Windows Settings > Apps > Apps & features, select Enpass and click the Modify button. Elevate privileges through User Account Control if necessary/prompted. Click Repair.
After repair completes, reboot your computer.
After rebooting, the first time you attempt to have Enpass fill login fields, you will be prompted to authorize Enpass browser extensions to access Enpass (you will see a prompt for and automatically be provided a 6-digit code). I encountered this separately for Google Chrome and Microsoft Edge, but not Mozilla Firefox. In Firefox, it simply worked. I guess authorization for the Enpass Firefox extension survived Enpass repair, etc.
While I can't pinpoint exactly when this started, I think the upgrade to 6.7.4 (933) wasn't as seamless/smooth as usual. I don't think the problem was related to updates to Chrome or other browsers. I encountered the same trouble in Google Chrome, Microsoft Edge, and Mozilla Firefox. I discovered that I had both the Enpass Windows API (Win32) and Microsoft Store (modern app) editions installed. It's unclear to me how this happened. I recall installing the Microsoft Store edition some time ago, perhaps around the time Enpass was first available in the Store app. I decided to continue using Enpass Windows API edition instead, and I thought I had uninstalled Enpass Microsoft Store edition. This wouldn't remove the Enpass app from my "purchased" apps or Microsoft Store app library. I'm wondering if a subsequent Enpass update or possibly a Windows/Microsoft Store app update caused the Enpass app to reinstall...
Hope this is helpful.